| Research area: Attention Deficit Disorder |
| Does sucrose or aspartame cause hyperactivity in children? |
Kanarek RB. |
Nutr Rev. 1994 May;52(5):173-5. |
| Aspartame: effects on learning, behavior, and mood. |
Saravis S, Schachar R, Zlotkin S, Leiter LA, Anderson GH. |
Pediatrics. 1990 Jul;86(1):75-83. |
| Aspartame, behavior, and cognitive function in children with attention deficit disorder. |
Shaywitz BA, Sullivan CM, Anderson GM, Gillespie SM, Sullivan B, Shaywitz SE. |
Pediatrics. 1994 Jan;93(1):70-5. |
| Erythrocyte L-aspartyl-L-phenylalanine hydrolase activity and plasma phenylalanine
and aspartate concentrations in children consuming diets high in aspartame. |
Stegink LD, Lindgren SD, Brummel MC, Stumbo PJ, Wolraich ML. |
Am J Clin Nutr. 1995 Dec;62(6):1206-11. |
| Effects of diets high in sucrose or aspartame on the behavior and cognitive performance of children. |
Wolraich ML, Lindgren SD, Stumbo PJ, Stegink LD, Appelbaum MI, Kiritsy MC. |
N Engl J Med. 1994 Feb 3;330(5):301-7. |
| Treatment of hyperactive children with D-phenylalanine. |
Zametkin AJ, Karoum F, Rapoport JL. |
Am J Psychiatry. 1987 Jun;144(6):792-4. |
| Research area: Appetite, Intake and Weight Maintenance |
| Aspartame: effect on lunch-time food intake, appetite and hedonic response in children. |
Anderson GH, Saravis S, Schacher R, Zlotkin S, Leiter LA. |
Appetite. 1989 Oct;13(2):93-103. |
| Intense sweeteners, energy intake and the control of body weight. |
Bellisle F, Drewnowski A |
European Journal of Clinical Nutrition, 10, 1038 (2007). |
| Soft drinks with aspartame: effect on subjective hunger, food
selection, and food intake of young adult males. |
Black RM, Tanaka P, Leiter LA, Anderson GH. |
Physiol Behav. 1991 Apr;49(4):803-10. |
| Effects of consumption of caloric vs noncaloric sweet drinks on indices
of hunger and food consumption in normal adults. |
Canty DJ, Chan MM. |
Am J Clin Nutr. 1991 May;53(5):1159-64. |
| Effects of aspartame and sucrose on hunger and energy intake in humans. |
Mattes R. |
Physiol Behav. 1990 Jun;47(6):1037-44. |
| Use of artificial sweeteners and fat-modified foods in weight loss maintainers and always-normal weight individuals |
Phelan S, Lang W, Jordan D, Wing R |
International Journal of Obesity 28 July 2009; 10:1038 |
| The effect of non-nutritive sweeteners on body weight in rats. |
Porikos KP, Koopmans HS. |
Appetite. 1988;11 Suppl 1:12-5. |
| Effect of covert nutritive dilution on the spontaneous food
intake of obese individuals: a pilot study. |
Porikos KP, Booth G, Van Itallie TB. |
Am J Clin Nutr. 1977 Oct;30(10):1638-44. |
| Intense sweeteners, food intake, and the weight of a body of evidence. |
Renwick AG. |
Physiol Behav. 1994 Jan;55(1):139-43. |
| Comparative effects of fructose, aspartame, glucose, and water
preloads on calorie and macronutrient intake. |
Rodin J. |
Am J Clin Nutr. 1990 Mar;51(3):428-35. |
| Effects of intense sweeteners on hunger, food intake, and body weight: a review. |
Rolls BJ. |
Am J Clin Nutr. 1991 Apr;53(4):872-8. |
| Comparison of the effects of aspartame and sucrose on appetite and food intake. |
Rolls BJ, Hetherington M, Laster LJ. |
Appetite. 1988;11 Suppl 1:62-7. |
| Hunger and food intake following consumption of low-calorie foods. |
Rolls BJ, Laster LJ, Summerfelt A. |
Appetite. 1989 Oct;13(2):115-27. |
| Effects of drinks sweetened with sucrose or aspartame on hunger,
thirst and food intake in men. |
Rolls BJ, Kim S, Fedoroff IC. |
Physiol Behav. 1990 Jul;48(1):19-26. |
| Effect of drinking soda sweetened with aspartame or high-fructose
corn syrup on food intake and body weight. |
Tordoff MG, Alleva AM. |
Am J Clin Nutr. 1990 Jun;51(6):963-9. |
| Effects of sugar intake on body weight: a review. |
Vermunt SH, Pasman WJ, Schaafsma G, Kardinaal AF. |
Obes Rev. 2003 May;4(2):91-9. |
| A review of the effectiveness of aspartame in helping with weight control |
Hunty A, Gibson S, Ashwell M. |
Nutrition Bulletin, 31, 115-128 (2006). |
| Research area: Arthritis |
| The biological properties of aspartame. V. Effects on a variety of
physiological parameters related to inflammation and metabolism. |
Aspinall RL, Saunders RN, Pautsch WF, Nutting EF. |
J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):387-95. |
| Research area: Cancer |
| Incidence of brain tumors in rats fed aspartame. |
Ishii H. |
Toxicol Lett. 1981 Mar;7(6):433-7. |
| Mycoplasma pulmonis and Lymphoma in Bioassays in Rats. |
T Schoeb, E McConnell, M. Juliana, J Davis, M Davidson and J Lindsey. |
Veterinary Pathology 2009: 802401 - 80240 |
| Research area: Diabetes |
| Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects. |
Filer LJ Jr, Stegink LD. |
Diabetes Care. 1989 Jan;12(1):67-74. |
| Response to single dose of aspartame or saccharin by NIDDM patients. |
Horwitz DL, McLane M, Kobe P. |
Diabetes Care. 1988 Mar;11(3):230-4. |
| Aspartame use by persons with diabetes.M |
Nehrling JK, Kobe P, McLane MP, Olson RE, Kamath S, Horwitz DL. |
Diabetes Care. 1985 Sep-Oct;8(5):415-7. |
| Glucose tolerance, blood lipid, insulin and glucagon concentration
after single or continuous administration of aspartame in diabetics. |
Okuno G, Kawakami F, Tako H, Kashihara T, Shibamoto S, Yamazaki T, Yamamoto K, Saeki M. |
Diabetes Res Clin Pract. 1986 Apr;2(1):23-7. |
| Effects of aspartame on diabetic rats and diabetic patients. |
Shigeta H, Yoshida T, Nakai M, Mori H, Kano Y, Nishioka H,
Kajiyama S, Kitagawa Y, Kanatsuna T, Kondo M, et al. |
J Nutr Sci Vitaminol (Tokyo). 1985 Oct;31(5):533-40. |
| Administration of aspartame in non-insulin-dependent diabetics. |
Stern SB, Bleicher SJ, Flores A, Gombos G, Recitas D, Shu J. |
J Toxicol Environ Health. 1976 Nov;2(2):429-39. |
| Research area: Headache |
| Aspartame and susceptibility to headache. |
Schiffman SS, Buckley CE 3rd, Sampson HA, Massey EW, Baraniuk JN, Follett JV, Warwick ZS. |
N Engl J Med. 1987 Nov 5;317(19):1181-5. |
| Research area: Hypersensitivity |
| A combined single-blind, double-blind, placebo-controlled study to determine the
reproducibility of hypersensitivity reactions to aspartame. |
Garriga MM, Berkebile C, Metcalfe DD. |
J Allergy Clin Immunol. 1991 Apr; 87(4):821-7. |
| Research area: Methanol, Formaldehyde and Formic Acid |
| Metabolism of aspartame and its L-phenylalanine methyl ester
decomposition product by the porcine gut. |
Burgert SL, Andersen DW, Stegink LD, Takeuchi H, Schedl HP. |
Metabolism. 1991 Jun;40(6):612-8. |
| Cytotoxic effects of methanol, formaldehyde, and formate on dissociated
rat thymocytes: a possibility of aspartame toxicity. |
Oyama Y, Sakai H, Arata T, Okano Y, Akaike N, Sakai K, Noda K. |
Cell Biol Toxicol. 2002;18(1):43-50. |
| Comparative metabolism of aspartame in experimental animals and humans. |
Ranney RE, Oppermann JA, Muldoon E, McMahon FG. |
J Toxicol Environ Health. 1976 Nov;2(2):441-51. |
| Aspartame, behavior, and cognitive function in children with attention deficit disorder. |
Shaywitz BA, Sullivan CM, Anderson GM, Gillespie SM, Sullivan B, Shaywitz SE. |
Pediatrics. 1994 Jan;93(1):70-5. |
| The aspartame story: a model for the clinical testing of a food additive. |
Stegink LD. |
Am J Clin Nutr. 1987 Jul;46(1 Suppl):204-15. |
| Blood methanol concentrations in normal adult subjects administered abuse doses of aspartame. |
Stegink LD, Brummel MC, McMartin K, Martin-Amat G, Filer LJ Jr, Baker GL, Tephly TR. |
J Toxicol Environ Health. 1981 Feb;7(2):281-90. |
| Blood methanol concentrations in one-year-old infants administered graded doses of aspartame. |
Stegink LD, Brummel MC, Filer LJ Jr, Baker GL. |
J Nutr. 1983 Aug;113(8):1600-6. |
| Effect of repeated ingestion of aspartame-sweetened beverage on plasma amino acid, blood
methanol, and blood formate concentrations in normal adults. |
Stegink LD, Filer LJ Jr, Bell EF, Ziegler EE, Tephly TR. |
Metabolism. 1989 Apr;38(4):357-63. |
| Comments on the purported generation of formaldehyde and
adduct formation from the sweetener aspartame. |
Tephly TR. |
Life Sci. 1999;65(13):PL157-60. |
| Research area: Parkinson's Disease |
| Aspartame use in Parkinson's disease. |
Karstaedt PJ, Pincus JH. |
Neurology. 1993 Mar;43(3 Pt 1):611-3. |
| Research area: Pregnancy |
| Use of aspartame in pregnancy. |
Sturtevant FM. |
Int J Fertil. 1985;30(1):85-7. |
| Research area: Reproduction |
| Effects of perinatal exposure to aspartame on rat pups. |
Holder MD. |
Neurotoxicol Teratol. 1989 Jan-Feb;11(1):1-6. |
| The biological properties of aspartame. IV. Effects on reproduction and lactation. |
Lennon HD, Metcalf LE, Mares SE, Smith JH, Nutting EF, Saunders FJ. |
J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):375-86. |
| Absence of developmental effects in CF-1 mice exposed to aspartame in utero. |
McAnulty PA, Collier MJ, Enticott J, Tesh JM, Mayhew DA, Comer CP, Hjelle JJ, Kotsonis FN. |
Fundam Appl Toxicol. 1989 Aug;13(2):296-302. |
| Research area: Safety |
| Acceptable daily intake vs actual intake: the aspartame example. |
Butchko HH, Kotsonis FN. |
J Am Coll Nutr. 1991 Jun;10(3):258-66. |
| Aspartame: scientific evaluation in the postmarketing period. |
Butchko HH, Stargel WW. |
Regul Toxicol Pharmacol. 2001 Dec;34(3):221-33. |
| Postmarketing surveillance of food additives. |
Butchko HH, Tschanz C, Kotsonis FN. |
Regul Toxicol Pharmacol. 1994 Aug;20(1 Pt 1):105-18. |
| Aspartame: review of safety. |
Butchko HH et al. |
Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 2):S1-93. |
| Use of aspartame by apparently healthy children and adolescents. |
Frey GH. |
J Toxicol Environ Health. 1976 Nov;2(2):401-15. |
| Aspartame intolerance. |
Garriga MM, Metcalfe DD. |
Ann Allergy. 1988 Dec;61(6 Pt 2):63-9. |
| Non-nutritive Intense Sweeteners in Diabetes Management. |
Gougeon R, Spidel M, Lee K, Field CJ |
Canadian Journal Of Diabetes. 2004;28(4):385-399. |
| Aspartame. Review of safety issues. Council on Scientific Affairs. |
[No authors listed] |
JAMA. 1985 Jul 19;254(3):400-2. |
| Safety of long-term large doses of aspartame. |
Leon AS, Hunninghake DB, Bell C, Rassin DK, Tephly TR. |
Arch Intern Med. 1989 Oct;149(10):2318-24. |
| Acceptable daily intake and the regulation of intense sweeteners. |
Renwick AG. |
Food Addit Contam. 1990 Jul-Aug;7(4):463-75. |
| Clinical safety of aspartame. |
Yost DA. |
Am Fam Physician. 1989 Feb;39(2):201-6. |
| Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological Studies |
Magnuson BA et al. |
Critical Reviews in Toxicology, 37:629-727. |
| Artificial sweeteners and cancer risk in a network of case-control studies |
Gallus S et al. |
Annals of Oncology, January 2007 18(1):40-44. |
| Research area: Seizure |
| Aspartame fails to facilitate pentylenetetrazol-induced convulsions in CD-1 mice. |
Dailey JW, Lasley SM, Mishra PK, Bettendorf AF, Burger RL, Jobe PC. |
Toxicol Appl Pharmacol. 1989 May;98(3):475-86. |
| Amino acids, monoamines and audiogenic seizures in genetically
epilepsy-prone rats: effects of aspartame. |
Dailey JW, Lasley SM, Burger RL, Bettendorf AF, Mishra PK, Jobe PC. |
Epilepsy Res. 1991 Mar;8(2):122-33. |
| Interspecies and interstrain studies on the increased susceptibility
to metrazol-induced convulsions in animals given aspartame. |
Diomede L, Romano M, Guiso G, Caccia S, Nava S, Salmona M. |
Food Chem Toxicol. 1991 Feb;29(2):101-6. |
| Effect of aspartame on seizures in various models of experimental epilepsy. |
Guiso G, Caccia S, Vezzani A, Stasi MA, Salmona M, Romano M, Garattini S. |
Toxicol Appl Pharmacol. 1988 Dec;96(3):485-93. |
| Lack of effect of aspartame or of L-phenylalanine on photically
induced myoclonus in the baboon, Papio papio. |
Meldrum BS, Nanji N, Cornell RG. |
Epilepsy Res. 1989 Jul-Aug;4(1):1-7. |
| Aspartame and seizure susceptibility: results of a
clinical study in reportedly sensitive individuals. |
Rowan AJ, Shaywitz BA, Tuchman L, French JA, Luciano D, Sullivan CM. |
Epilepsia. 1995 Mar;36(3):270-5. |
| Pharmacological effects of phenylalanine on seizure susceptibility: an overview. |
Sze PY. |
Neurochem Res. 1989 Feb;14(2):103-11. |
| Oral administration of aspartame is not proconvulsant in rats. |
Tilson HA, Thai L, Zhao D, Sobotka TJ, Hong JS. |
Neurotoxicology. 1989 Summer;10(2):229-38. |
| An analysis of FDA passive surveillance reports of
seizures associated with consumption of aspartame. |
Tollefson L, Barnard RJ. |
J Am Diet Assoc. 1992 May;92(5):598-601. |
| Neuropsychological and biochemical investigations in heterozygotes for
phenylketonuria during ingestion of high dose aspartame
(a sweetener containing phenylalanine). |
Trefz F, de Sonneville L, Matthis P, Benninger C, Lanz-Englert B, Bickel H. |
Hum Genet. 1994 Apr;93(4):369-74. |
| Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats. |
Zhi JQ, Levy G. |
Res Commun Chem Pathol Pharmacol. 1989 Oct;66(1):171-4. |
