Aspartame has a history of more than 25 years safe use all around the world. It is probably the most thoroughly tested ingredient in our food supply. It has been the subject of more than 200 scientific studies, many of which have been conducted at world-class research institutes and universities.
Studies and Reviews:
Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological Studies (2007)
B. A. Magnuson, G. A. Burdock, J. Doull, R. M. Kroes, G. M. Marsh, M. W. Pariza, P. S. Spencer, W. J. Waddell, R. Walker and G. M. Williams
A panel of internationally renowned experts reviewed more than 500 studies, articles and reports on aspartame, concluding that, "The weight of existing evidence is that aspartame is safe at current levels of consumption."
Safety of long-term large doses of aspartame (1989)
A. S. Leon, D. B. Hunninghake, C. Bell, D. K. Rassin, T. R. Tephly
Long-term consumption of large doses of aspartame (the equivalent of the amount in approximately 10L of soft drink/day) is safe.
Artificial Sweeteners and the Risk of Gastric, Pancreatic, and Endometrial Cancers in Italy (2007)
S. Gallus, R. Talamini, M. Montella, S. Franceschi, E. Negri and C. La Vecchia
The consumption of low calorie sweeteners (including aspartame) does not lead to a risk of cancer.
The science on aspartame has been reviewed by the Joint Expert Committee on Food Additives of the United Nations Food and Agriculture Organisation and the World Health Organisation (JECFA), by the United States Food and Drug Administration (FDA), the European Food Safety Authority (EFSA) and by regulatory authorities in more than 100 countries around the world. All of these organisations have found aspartame to be safe.
European Commission's Scientific Committee on Food
In 2002, the European Commission's Scientific Committee on Food (SCF), predecessor to the EFSA reaffirmed the safety of aspartame and stating that:
"Aspartame is unique among the intense sweeteners in that the intake of its component parts can be compared with intakes of the same substances from natural foods."
The SCF previously reviewed the science on aspartame in 1984, 1988 and 1997. On each of these occasions the SCF found aspartame to be safe.
"The FDA has completed its review concerning the long-term carcinogenicity study of aspartame, conducted by the European Ramazzini Foundation. These data do not provide evidence to alter FDA's conclusion that the use of aspartame is safe."
In a statement published on 28 February 2011, the European Food Safety Authority (EFSA) reconfirmed its opinion that aspartame is safe, stating that:
"EFSA concluded that the information available from the Soffritti et al. (2010) and Halldorsson et al. (2010) publications do not give reason to reconsider the previous evaluations of aspartame or of other food additive sweeteners authorised in the European Union."